The general function of deacetylation with the lysine residues is carried out by HDAC enzymes. Apart from this pair of HDACs there exists another enzyme which performs a similar function. The name with this enzyme is SIRT1 also it removes the acetyl group by way of a very unique mechanism. The end product of this enzyme mediated reaction is nicotinamide. Removal of acetyl group by HDACs doesn't involve NAD+ hydrolysis. Inhibitors like trichostatin A, which show specific action against HDACs don't have any action against SIRT1. In 2018, we need: In the 18th century, the western countries successively carried out the industrial revolution, the universal adoption of large machinery, laid the foundation for the establishment of factory system. In 1771, British man Richard arkwright1732-1792 founded the first cotton-yarn factory in the city of kron. In the 1930s and 1940s, the factory system was established in Britain, Germany and other countries. The main sex of factory system is: to carry out large-scale intensive labor; Using big machine to improve efficiency production; Implement the employment system; The division of labor is deepening and production is socialized. The establishment of factory system marks the real birth of enterprises. Interest rate decisions on Thursday are expected to see the bank of England hold interest rates and provide the latest update on the economy since last month. The fund's managing director Christine Lagarde said Christine Lagarde, in June 2016, voted to leave the European Union has an impact, the British economic growth this year and in other parts of the world economic growth.