Philip Hammond has been trying to persuade conservatives that tax increases and spending cuts are needed to reduce the deficit. During the depression, the rate of interest reduction, the expansion of money supply, stimulate economic development. During the expansion period, the interest rate increases, the money supply is reduced, and the economic development is suppressed. So, interest rates have a big impact on our lives. The fund's managing director Christine Lagarde said Christine Lagarde, in June 2016, voted to leave the European Union has an impact, the British economic growth this year and in other parts of the world economic growth. The general function of deacetylation with the lysine residues is carried out by HDAC enzymes. Apart from this pair of HDACs there exists another enzyme which performs a similar function. The name with this enzyme is SIRT1 also it removes the acetyl group by way of a very unique mechanism. The end product of this enzyme mediated reaction is nicotinamide. Removal of acetyl group by HDACs doesn't involve NAD+ hydrolysis. Inhibitors like trichostatin A, which show specific action against HDACs don't have any action against SIRT1. At present, about the nature of the enterprise. Western economists have different views. There is also some debate. Some western economists analyze the nature of the enterprise mainly from the perspective of transaction costs that coase emphasizes. Most western interest-rate determinism focuses on the analysis of supply and demand comparisons, arguing that interest rates are a price. The difference lies in what supply and demand determines interest rates. For example, Marshall's real interest rate theory emphasizes the real factors of non-monetary factors - productivity and the role of economy in determining interest rate decisions. Productivity is expressed by marginal propensity to invest, and the marginal propensity to save is expressed.