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Starting since 1769, the 1st human transport was created with steam-powered fuel. In 1885, the very first car with ubiquitous modern gasoline or petrol fueled internal combustion engine appeared with thanks to the achievements of fuel gas car in 1806. The influence of automotive industry on the globe companies are so significant that nowadays this is just about the most important economic sectors by revenue. One of the easiest ways that companies can avoid animal exams are to use items that are already extensively found in human history and also have proven their safety over time. Companies could also depend upon data from natural and synthetic ingredients which are already previously tested on animals. Computer modeling and databases may be used to determine biological properties of ingredients and make risk assessments.