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One of the easiest ways that companies can avoid animal testing is to work with products that are actually extensively utilized in human history and still have proven their safety after a while. Companies also can depend on data from natural and synthetic substances that are already previously tested on animals. Computer modeling and databases may be used to determine biological properties of ingredients making risk assessments. Jonathan Brandstein, Patrice O'Neal's manager, said the family wanted to thank "all in the fans and friends who've expressed an outpouring of love and support for Patrice these past weeks." "Many of us have mislaid an in depth and loved friend; all of us have lost a genuine comic genius' Jonathan Brandstein said in a very statement. Charlie Sheen who had been fired through the hit CBS comedy 'Two and a Half Men' in September tweeted: "The entertainment world and also the world most importantly lost a brilliant man. Patrice O'Neal would have been a regular guest around the program 'Opie & Anthony Radio Show' and was a familiar face at some New York City TV shows including "Chappelle Show," "The Office," and "Tough Crowd with Colin Quinn. Patrice O'Neal's death was announced on Twitter by Opie in the Opie & Anthony Radio Show on Sirius/XM satellite radio: 'Yes, it's true that our pal Patrice O'Neal has passed away,' Opie tweeted. 'The funniest as well as thinker I've ever known PERIOD. #devastated." The details of his funeral is going to be updated soon.