Low Nitric Oxide Levels Despite their small size, Black Widow Spiders employ a very potent venom. It has been said that their venom is a bit more powerful compared to coral snakes and cobra snakes. The venom of a female Black Widow Spider is a bit more harmful than that of the males, but the probability of death is pretty small although negative effects can be quite unpleasant. The venom from all of these spiders is a lot more powerful than the venom of many other spiders. Their venom is known as neurotoxic where there are a couple of active components inside such as Latrotoxins and Adenosine. Some arthritis, such as rheumatoid arthritis and lupus, affects multiple organs and causes a wide range of symptoms.