Health-related evidence Although a lot of women will immediately suspect actually already checking menopausal period when they've many of the symptoms mentioned above, this isn't always the situation. This is because there's a term used for the period before menopause, when all these symptoms could be experienced, and that is perimenopause. Fibromyalgia - causes pain in body muscles, ligaments and tendons. It works just like prescription drugs, to increase nitric oxide release and inhibit PDE-5.