Langer-Giedion Syndrome is often a true contiguous gene deletion syndrome due to deletions both in the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be noticed in patients. The EXT1 gene and the TRPS1 gene tend to be absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 may be deleted or non-functional also. Longer deletions in this area are characterized by mental retardation and also the other variations in symptoms stated previously. I must also applaud the teachers and organizers of Shilp Encounter for the range of topics for debate. Topics varied from downsides of Interactive Media, are young netas as being a role model for today’s youth, introduction of recreational trips and camps at school trips like a form a practical learning, a place travelled is much more compared to a thousand books read plus a one who has not yet travelled any where hasn't experienced life fully. For others, physical menopause symptoms can include hot flashes and/or night sweats and vaginal dryness. Others could have problems in bladder control as well as other discomforting indications such as headache, fatigue, heart palpitation and muscle and joint pain. A majority of females could possibly have sleep problems and may even experience emotional menopause symptoms like moodiness, depression and irritability. Menopause symptoms also can influence a female?s sexuality. Others may have decreased libido and may have difficulty getting sexually excited and be less sensitive. Sex may even be painful on account of vaginal dryness or thinning from the vaginal tissue. Still there is a proportion of women who consider menopause a blessing as sex becomes more enjoyable since there are no pregnancy concerns anymore.