Serious loss of cartilage can cause the bones to rub over the bones, changing the shape of the joints, forcing the bones out of their normal position. Corticosteroids: prednisone and cortisone reduce inflammation and suppress the immune system. Estrogen imbalance has many causes, from abnormal function of the ovaries to normal processes including menopause. When the body makes an excessive amount of estrogen, method . 'excess estrogen." Symptoms of excess estrogen range from rapid, unexplained extra weight, breast tenderness, headaches, heavy periods, mood swings, and anxiety. Often, these symptoms are generated by hormone replacement therapy patients taking excessive a dose of estrogen to combat the the signs of menopause (Lee). The thyroid gland is situated in the low neck in the front. It looks just like a butterfly and produces those hormones triiodothyronine and thyroxine. These hormones are responsible for controlling how fast cells burn the fuels from food to generate energy. Thyrotropin controls thyroid hormone production and release. The pituitary gland secretes it.