Princely situated on the Israeli Mediterranean coastline, the city of Tel Aviv is one of the most beautiful and second most populous cities in Israel. The city of Tel Aviv continues to be one of the most favorite and exquisite tourist?s places in the world. The tourists from different corners of the world go here to experience thriving nightlife, famous 24-hour culture and young atmosphere of the city. People often call it "the city that never sleeps" and "party capital". Langer-Giedion Syndrome can be a true contiguous gene deletion syndrome a result of deletions in the the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be affecting patients. The EXT1 gene as well as the TRPS1 gene are both absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 might be deleted or non-functional also. Longer deletions in this region are seen as mental retardation as well as the other variations in symptoms stated earlier. Deep, relaxed breathing relaxes stressed- out body and oxygenates the blood. Calvin Klein might have not the first one to set up the initial designer underwear brand; however, the 1992 iconic marketing campaign with 18-year-old Kate Moss considerably set up his fashion compass. In the underwear advertising images, Mark Wahlberg and Kate Moss go topless wearing pants hitched up on the waistband and apply no make-up.