Freckles, much like age spots, are generated by excessive sun exposure. The harmful sunshine damage the melanocytes in the skin. These melanocytes are the type that help produce melanin pigment which are fed in to the skin cells that make up the exterior layer of the skin. It serves as a protection or a barrier in the harmful effects of the sun plus the impact caused by various conditions. When melanocytes are damage, small brown leafy spots show up on the face area, that are known as freckles. The severe the harm towards the melanocytes, there can be a top concentration of freckles on affected areas. Some people are certainly not bothered but the concentration of freckles inside their skin, but there are also many people who are very conscious in the darkish spots on their own face. As such, they seek information on the very best strategy for freckle removal. Even Dave Mustaine couldn?t have imagined how influential the lyrics in the Megadeth song, Tout Le Monde, would become. And one can simply imagine, a bemused Dr. House sitting alone in their office, together with his headphones plugged in, and the same song blaring from it. Trying to overlook the pain in his leg and in the mind from his failed relationship with Dr. Cuddy, House is almost repentant, almost! Gout - A type of arthritis caused by excessive uric acid in the body. This can stay in the joints (usually affecting the big toe), but can develop in any joint. It can cause severe pain, redness and swelling.