Princely situated on the Israeli Mediterranean coastline, the city of Tel Aviv is one of the most beautiful and second most populous cities in Israel. The city of Tel Aviv continues to be one of the most favorite and exquisite tourist?s places in the world. The tourists from different corners of the world go here to experience thriving nightlife, famous 24-hour culture and young atmosphere of the city. People often call it "the city that never sleeps" and "party capital". Bacteria can spread an infection through small fissures that may increase inside the dried-out skin round the heel and so on the rest from the foot or via corns, calluses, blisters, hangnails, or ulcers. If the treatment cannot come from perfect time, the bacterial infection can destroy skin, tissue, and bone or spread through throughout the body. There are some symptoms: Although the exact cause of JIA is unclear, as children grow older, symptoms often improve, which means they can live a normal life. The vast majority of patients who develop this arthropathy have diabetes mellitus. Specifically these patients have diabetic peripheral neuropathy. The incidence inside diabetic human population is about 8.5 per 1000 patients. There are approximately sixteen million diagnosed and undiagnosed diabetics within the United States population; and another approximately forty million individuals with impaired glucose tolerance which makes them predisposed to diabetes mellitus.