Langer-Giedion Syndrome is often a true contiguous gene deletion syndrome due to deletions both in the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be noticed in patients. The EXT1 gene and the TRPS1 gene tend to be absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 may be deleted or non-functional also. Longer deletions in this area are characterized by mental retardation and also the other variations in symptoms stated previously. Joint JIA Hypoglycemia, diagnosed in older times, had virtually no effect when diagnosed, on account of my excessive intake of chocolates, sweets and carbonated drinks, high in sugar, that became a practice developed after I quit drinking alcohol 23 in the past. This replaced by 3 to 4 litres of the certain soft drink being consumed on a daily basis, as well as the sweets and chocolates that was a habit for a long time, even whilst partaking in alcohol, merely assisted in keeping the glucose levels with an acceptable level. Getting All the Above Environmental pollutants which mimic the effects of estrogen inside our bodies are called xenoestrogens. We are confronted with these in several ways including car exhaust, pesticides, solvents (present in nail polish and remover), emulsifiers present in soap and cosmetics, plastics (think water bottles) and synthetic hormones found in birth control pills and other drugs which can be flushed into the sewers and back in our soil and water.