Very little is known regarding the reproductive habits of those cats. It is believed that the Asiatic cheetah tends to breed during the mid-winter months. Females are thought to possess one to four cubs during a period, but average two cubs at the same time. It is considered that cubs reach independence at about eighteen months old. It is estimated that approximately 50 to 75 percent of cubs do not live more than three months. Pediatric rheumatologists are pediatricians who have completed an additional 2-3 years of specialized training in pediatric rheumatology and are usually licensed in pediatric rheumatology. Langer-Giedion Syndrome is often a true contiguous gene deletion syndrome due to deletions both in the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be noticed in patients. The EXT1 gene and the TRPS1 gene tend to be absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 may be deleted or non-functional also. Longer deletions in this area are characterized by mental retardation and also the other variations in symptoms stated previously.