Health-related evidence Freckles are brown spots that show on the skin, especially on areas most confronted with the sun's rays. The face, chest and shoulders are most common locations where freckles develop. They are quite harmless but they can be be extremely unsightly should they give full attention to specific areas about the face, especially about the cheekbone as well as the nose area. This is particularly true with light-skinned people for the reason that brownish spots look like stains in an otherwise smooth and milky white skin. Brown-skinned or dark-skinned folks have it better since they have built-in protection with melatonin, as well as the realization they can readily hide their dark brown spots. Enteric Arthritis - a form of chronic inflammatory arthritis associated with inflammatory bowel disease (IBD), the two most famous of which are ulcerative colitis and Crohn's disease. About one in five patients with Crohn's or ulcerative colitis develop enteric arthritis. The most common site affected by inflammation is the peripheral (limbs) joints and spine. Drugs depend on the type of arthritis. Commonly used drugs include: