Psoriatic arthritis, an inflammatory joint disease that affects psoriatic patients. One must not delay in consulting any qualified infertility specialist if the result of unsecured sex does not show any hope of pregnancy. Those are below 35 years can try it for one year but the couples above 35 years must not wait for more than six months as an age factor can also prove a hurdle towards achieving the desired outcome.     Langer-Giedion Syndrome can be a true contiguous gene deletion syndrome a result of deletions in the the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be affecting patients. The EXT1 gene as well as the TRPS1 gene are both absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 might be deleted or non-functional also. Longer deletions in this region are seen as mental retardation as well as the other variations in symptoms stated earlier.