As of today, prevention is still, as it was before, loads better than cure. Langer-Giedion Syndrome is often a true contiguous gene deletion syndrome due to deletions both in the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be noticed in patients. The EXT1 gene and the TRPS1 gene tend to be absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 may be deleted or non-functional also. Longer deletions in this area are characterized by mental retardation and also the other variations in symptoms stated previously. Joint pain, stiffness and swelling are the most common symptoms of arthritis. Your range of exercise may also decrease, and you may become reddish around the joints. Many people with arthritis notice their symptoms are worse in the morning. Do you feel like your lovemaking is becoming a bit stale and boring? Do you feel like it is therefore affected your relationship using your partner? The fact is, you?re not the only one. Like you, there are several couples who weren't having sex normally while they employed to. Even when they did make love, it was just the same old tricks or patterns they always did.