Can lead to the nipple and areola color deepened. 2, Some physiological changes could also result in alterations in large from the nipple. Pregnancy led to increased estrogen and progesterone. Women after pregnancy, Starting from early pregnancy, the nipple and areola color deepened, by turns crimson through the light brown. Some women (under three decades old -45 years of age), the situation in the absence of pregnancy. Nipple and areola color deepened slowly. This color change suggests women have “one off"in the increased estrogen. Rheumatic diseases often involve pain, pain, stiffness and swelling, as well as swelling around one or more joints. Symptoms can appear gradually or suddenly. Some rheumatism also includes the immune system and various internal organs of the body. One of the differences that is noticeable in a very comparison of viruses and bacteria could be the height and width of the microorganism. Viruses less complicated smaller than bacteria. A typical virus is between 20 and 400 nanometers, while a bacterium can be as large as 1000 nanometers. The smallest bacteria are generally visible having a light microscope, while viruses require an electron microscope for observation.