One in the major human activities leading for the irreversible biodiversity loss is the overexploitation of certain animals. This occurs when the human destruction or usage of a species outpaces that species' capability to reproduce. This often occurs when certain organisms are highly prized by humans, which could be the case with animals and plants whose parts are utilized as medicinal therapies in most societies. Sadly, three with the Earth's eight species of tiger happen to be extinct. What's worse? The five remaining species are gravely endangered, partly due on the interest in their bones, which are believed to treat arthritis, and erroneously believed to reverse male impotence. Exploitation also affects plants as well including popular wild-grown medicines ' including Echinacea, the normal cold remedy. Biologics: Biologic response modifiers used with DMARDs are genetically engineered drugs that target various protein molecules involved in the immune response. Examples include Enbrel and Remicade. Secondary arthritis, an arthritis that develops after joint damage, can sometimes take years to come. Some of the best pills contain ingredients like hops extract, ginkgo, epimedium sagittatum, DHEA, melatonin etc.