This blood test is often ordered within a patient's yearly physical exam to confirm how well their kidneys are functioning. This test can also be ordered every time a patient is acutely ill or when a doctor suspects kidney problems. The following symptoms often result in a doctor using a creatinine blood test: fatigue, loss in appetite, difficulty sleeping, concentration problems, decreased production of urine, trouble urinating, urinating more regularly, hypertension, pain in the mid-back, brown or foamy urine, blood inside urine, and swelling from the eyes, ankles, face, thighs, abdomen or wrists. These symptoms often indicate kidney dysfunction therefore this blood test will probably be performed to diagnose the challenge as well as to rule out kidney dysfunction because the cause. It most often develops in adults over the age of 40. It is also more common in women and in people with a family history. However, it can occur at any age due to injury or other joint-related diseases such as gout or rheumatoid arthritis. Non-steroidal anti-inflammatory drugs (non-steroidal anti-inflammatory drugs): can reduce pain and inflammation. Over-the-counter NSAIDs include ibuprofen (Advair, Motolin IB) and naproxen sodium (Aleve). Some non-steroidal anti-inflammatory drugs can be used as creams, gels or patches that can be applied to specific joints. Can lead to the nipple and areola color deepened. 2, Some physiological changes could also result in alterations in large from the nipple. Pregnancy led to increased estrogen and progesterone. Women after pregnancy, Starting from early pregnancy, the nipple and areola color deepened, by turns crimson through the light brown. Some women (under three decades old -45 years of age), the situation in the absence of pregnancy. Nipple and areola color deepened slowly. This color change suggests women have “one off"in the increased estrogen.