4. Try Something Thrilling Disease-Resistant Anti-Rheumatic Drugs (DMARDs): Used to treat RA, DMARDs slow or stop the immune system from attacking the joints. Such as Trexall and Plaquenil. Normal wear leads to OA, which is one of the most common forms of arthritis. Infection or injury to the joints can exacerbate this natural breakdown of cartilage tissue. If you have a family history of the disease, your risk of developing OA may be even higher.