The following discusses the main types of JIA. Arthritis research in the UK has more information on different types of juvenile idiopathic arthritis. Recently， some pictures of Lady Gaga who had been cooking on her friend were uploaded onto the her blog, Lady Gaga show out her “shocking style ” vividly. This time she was in the home , cooking for her friend, but without wearing an apron, only wearing underwear when she was cooking, and smoking the cigar while she was cooking,. The picture was uploaded by her friend Fernando Gabiray, and he or she made a comment under the picture “ Another shocking time comes again, we wont pay should you die, Gaga is cooking to me virtuously now ." Can lead to the nipple and areola color deepened. 2, Some physiological changes could also result in alterations in large from the nipple. Pregnancy led to increased estrogen and progesterone. Women after pregnancy, Starting from early pregnancy, the nipple and areola color deepened, by turns crimson through the light brown. Some women (under three decades old -45 years of age), the situation in the absence of pregnancy. Nipple and areola color deepened slowly. This color change suggests women have “one off"in the increased estrogen. Langer-Giedion Syndrome is often a true contiguous gene deletion syndrome due to deletions both in the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be noticed in patients. The EXT1 gene and the TRPS1 gene tend to be absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 may be deleted or non-functional also. Longer deletions in this area are characterized by mental retardation and also the other variations in symptoms stated previously. This will aid elimination of harmful bacteria through washing them away in the process of urination