Langer-Giedion Syndrome is often a true contiguous gene deletion syndrome due to deletions both in the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be noticed in patients. The EXT1 gene and the TRPS1 gene tend to be absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 may be deleted or non-functional also. Longer deletions in this area are characterized by mental retardation and also the other variations in symptoms stated previously. In the case of RA, you may feel tired or suffer from loss of appetite due to inflammation caused by immune system activity. You may also become anemic - meaning you have fewer red blood cells - or have a mild fever. Severe RA may lead to joint deformities, if not treated. And the man gets clinically determined to have the male impotence. The official party line of the American Medical Assn is actually there's no diabetes (measurable sugar affect), then there's no sugar problem. As is a fact of life, they're WRONG! The problem is virtually always a sugar problem. Of course, Big Pharma doesn?t would love you to understand your cause is.