Anti-irritants: Some ointments and ointments contain peppermint or capsaicin, which is a spicy hot pepper ingredients. Friction on the painful joints can regulate joint pain signals and relieve pain. Getting All the Above Biologics: Biologic response modifiers used with DMARDs are genetically engineered drugs that target various protein molecules involved in the immune response. Examples include Enbrel and Remicade. Some couples may be unaware with the fact that sex plays an important role in the relationship; it keeps you closer and more intimate.