You have no idea just how much the efficiency and function of your appliances and installations depend upon how clean these are. Here is a great example on what the general cleanness of your furnace filter can in fact improve how your property is heated over the winter season. A dirty furnace filter's a recipe for the cold home, but large energy bills nonetheless. Do yourself a favour and learn to clean and change a filter, to help you avoid these issues. Langer-Giedion Syndrome can be a true contiguous gene deletion syndrome a result of deletions in the the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be affecting patients. The EXT1 gene as well as the TRPS1 gene are both absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 might be deleted or non-functional also. Longer deletions in this region are seen as mental retardation as well as the other variations in symptoms stated earlier. The new architecture also means the pages on the content rich site now load in milliseconds, ensuring that potential customers visiting the site are engaged for long enough to register their interest.