Langer-Giedion Syndrome is often a true contiguous gene deletion syndrome due to deletions both in the TRPS and EXT1 genes. The lack of a functional EXT1 gene causes the bone exostoses, bone anomalies and facial abnormalities which can be noticed in patients. The EXT1 gene and the TRPS1 gene tend to be absent in patients and research suggests that other genes based in the 8q24.11-8q24.13 region of chromosome 8 may be deleted or non-functional also. Longer deletions in this area are characterized by mental retardation and also the other variations in symptoms stated previously. These treatments also apply to the types of inflammation of arthritis, such as rheumatoid arthritis, as well as anti-inflammatory drugs such as corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs), anti-rheumatic drugs (DMARDs ), As well as a relatively new drug called a biologic. There may be a misconceived perception that nearshore software developers are vastly different culturally and might have difficulties communicating due an absence of using a good grasp from the English language. This cannot be more wrong.Many IT university graduates from Latin America are bilingual with Spanish and English. Also, Spanish could be the second language spoken in U.S. homes either being a first or second language.